But I suspect in Prime 4, Samus is going to be on the receiving end of a lot of one-sided conversations.
When you first meet Myles, he's yapping to himself. "You're alone, on a planet, with no hope of survival. But, you're also not sitting next to Phil anymore in that cubicle. So… win?" He's a bespectacled engineering nerd, not the most hardened of Federation soldiers. He dangles off things and hollers for help. He screeches and runs for cover when enemies appear. Oh, yeah - he follows you around.
After you rescue Myles, a good deal of Metroid's atmospheric isolation is sapped away. The first time you transform into Samus' iconic ball form in front of him, he has a quip about it. When we approach a disabled mech, he introduces Samus to it. "You know her," he says to the inanimate object. "She's famous!" Myles also becomes a gameplay signpost. He warns as you approach a body of water where enemies lurk below the surface ready to pounce, for instance. As I deliberately walk past a save point without using it, he calls out from behind me.